“Erectile dysfunction” implies incapacity to achieve erection for accomplishing of fully-realized sexual intercourse. According to statistics, this pathology affects around 40% of representatives of the stronger sex at the age of 40 to 50 years. In case the disorder lasts more than 3-4 months, medicamentous therapy is required.
Sildenafil Citrate Profile
Sildenafil Citrate ProfileSildenafil and sildenafil-containing drugs are considered to be some of the most efficient remedies eliminating intimate issues. A real breakthrough in the area of sexual disorders therapy is Viagra the main substance of which is chemical composition sildenafil citrate. The main advantage of the pills is the fact that they are the first remedy for struggle against erectile dysfunction. In order to understand sildenafil principle of action, it is important to understand physiological principle of erection. The major part of penile structure belongs to cavernous bodies. Relaxation of their muscular tissue and filling with blood provide firmness of penis. This process is controlled by enzymes.
Under the influence of nerve impulse in the walls of cavernous bodies’ vessels, the release of nitrogen oxide takes place. This process causes accumulation of enzyme, cyclic guanosine monophosphate, or its reduction. This biologically active substance provides arterial blood stream to penis, and cavernous bodies grow in size. Blood deflux from penis stops and erection occurs. Upon termination of sexual activity, cyclic guanosine monophosphate gets destroyed by another enzyme, PDE5. The reversible process takes place. Sildenafil citrate has direct action on inhibition of PDE5 due to which erection preserves for a long time. Anyway, sildenafil intake will be beneficial only in case, a man feels sexual attraction to his partner. Otherwise, the drug will be useless.
Sildenafil is not only male and female stimulant; it was initially used for pulmonary hypertension. Now the remedy is used for elimination of organic, psychogenic and mixed types of erectile dysfunction. This medication is used for lax and unsteady erection, premature emission of seminal fluid, low libido, impotency, and impairment of blood circulation in pelvic organs. Sildenafil is prescribed regardless of age group of a patient. The medicine allows getting maximal pleasure of sexual activities by both men and women.
Sildenafil is applied perorally with a lot of water. The optimal variant of sildenafil administration is 1 hour prior to sexual intercourse. A man should not worry that erection will occur before its due time, since erection may appear only with sexual attraction. Drug’s action lasts in average six hours.
Therapy is better to be started with minimally effective dose of sildenafil. It should not surpass 25mg in case of hepatic or renal failures and cardio-vascular disorders. The drug is not to be combined with fatty food that slow down the absorption of sildenafil. The instruction reads that maximal daily dose of the medicine must not exceed 200mg.
With appearance of sildenafil on pharmaceutical market, a lot of research studies took place for disposing any side-effects and complications. First of all, it is important to state a real cause of sexual impairment and take sildenafil only after that.
Sildenafil may cause the following adverse affects:
- Vertigo, headache, buzzing, insomnia;
- Change of color perception, a man may see surrounding objects in blue color;
- Fluctuations of arterial blood pressure, tachycardia;
- Dryness in mouth, nausea;
- Frequent urination;
- Allergic rash, itches.
Very rarely, sildenafil intake may provoke priapism which means a long-term and uncontrolled (during a couple of hours) erection that is not connected with sexual arousal. In this case, immediate medical attendance is required. Combination of sildenafil with alcohol is still doubtful, since sometimes alcoholic drinks are inalienable part of a date and sexual intercourse.
Interaction of the drug with ethanol is fraught with the following consequences:
- Slowing down of sildenafil effect;
- Absence of sexual desire due to alcohol influence on male nervous system;
- Semen quality impairment;
- Toxic impacts on liver.
All in all, sildenafil is perfect for men suffering from erectile dysfunction of any level of severity. Besides, a lot of testimonials from doctors and patients prove that sildenafil is safe in case of strict observation of its instruction.